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An allergy can refer to several kinds of immune reactions including Type I hypersensitivity in which a person's body is hypersensitised and develops IgE type antibodies to typical proteins. When a person is hypersensitised, these substances are known as allergens. The word allergy derives from the Greek words allos meaning "other" and ergon meaning "work". Type I hypersensitivity is characterised by excessive activation of mast cells and basophils by immunoglobulin E resulting in a systemic inflammatory response that can result in symptoms as benign as a runny nose, to life-threatening anaphylactic shock and death.

Allergy is a very common disorder and more than 50 million Americans suffer from allergic diseases. Allergies are the 6th leading cause of chronic disease in the United States, costing the health care system $18 billion annually (Allergy statistics).

History


The term and concept of "allergy" was coined by a Viennese pediatrician named Clemens von Pirquet in 1906 *. He observed that the symptoms of some of his patients might have been a response to outside allergens such as dust, pollen, or certain foods. For a long time all hypersensitivities were thought to stem from the improper action of inflammatory immunoglobulin class IgE, however it soon became clear that several different mechanisms utilizing different effector molecules were responsible for the myriad of disorders previously classified as "allergies". A new four-class (now five) classification scheme was designed by P. G. H. Gell and R. R. A. Coombs. Allergy has since been kept as the name for Type I Hypersensitivity, characterised by classical IgE mediation of effects.

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@arwild01 Its just an unfortunate combination of genetics and allergies.
fignewton (fignewton) Fri, 06 Nov 2009 14:09:06 -0000
@arwild01 Its just an unfortunate combination of genetics and allergies.
might just be allergies. NasalCrom and Walmart's brand of Tavist 12-hour antihistimine are working nicely.
Mark_Cable (Mark Cable) Fri, 06 Nov 2009 14:09:05 -0000
might just be allergies. NasalCrom and Walmart's brand of Tavist 12-hour antihistimine are working nicely.
Don't feel so great this morning, tired, and my allergies are acting up. :P Blah. Playing Denton today
NicoleKardos (Nicole Kardos) Fri, 06 Nov 2009 14:08:05 -0000
Don't feel so great this morning, tired, and my allergies are acting up. :P Blah. Playing Denton today
Allergies #Allergies: Food Allergy Community Up in Arms Over Nut Article... http://bit.ly/4mA8R8
t_allergies (Allergies Topic) Fri, 06 Nov 2009 14:05:42 -0000
Allergies #Allergies: Food Allergy Community Up in Arms Over Nut Article... http://bit.ly/4mA8R8
Cobwebs: Great for goth aesthetic, not so great for allergies.
robot_smith (a rain love ink) Fri, 06 Nov 2009 14:01:49 -0000
Cobwebs: Great for goth aesthetic, not so great for allergies.
@endanubis allergies not giving you a problem w/all the pet hair??
JonicaG (Jonica Grodzicki) Fri, 06 Nov 2009 13:59:09 -0000
@endanubis allergies not giving you a problem w/all the pet hair??

 
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